Don't count your chickens before they've hatched

Two days post six day embryo transfer (2dp6dt)

'Having a baby is like getting a tattoo on your face. You really need to be certain it's what you want before you commit.' 
Elizabeth Gilbert 

From my last post up until 8:45am on Wednesday 9 April 2014 everything had been going tickety-boo. I've actually got three blog drafts saved that I'll never publish - they're going to remain drafts. In these drafts I've babbled on about The Lister hospital experience and compared it to a stay in a 5* hotel, with room service, great food, Molton Brown goodies and Sky TV. The only difference is you do actually have to go down to theatre and have a general anaesthetic and the nurses check in on you every 30 minutes afterwards. Below is a photo of me a few hours after egg collection, my blood pressure was very low at that point but I was overcome with joy when the food arrived - I was very hungry and I inhaled the lot. It was delicious!

Egg collection via general is FAR more civilised and I thoroughly recommend it. They managed to get 13 eggs, 10 were mature, six fertilised. Yep - we had six mini-mes and apparently fertilisation was easy - to quote the embryologist I spoke to three days post egg collection: 'Very easy fertilisation, in fact so easy I'm surprised you went for IMSI, from what I could see you would have been fine with straightforward IVF - the sample was grade 1 sperm. Your eggs were also top quality.' 

All six of our mini-mes were going strong on day three so we enthusiastically agreed to go for a day five / blastocyst transfer. We got a call on Tuesday from one of the embryologists telling us that four of our mini-mes hadn't reached blastocyst stage - they were what they called morulas - the other two were a wee bit behind but we should give it another day and give them a chance to develop a wee bit more. Again this was fine, day six transfers are perfectly normal. So when I got a No Caller ID phone call at 8:45am on Wednesday morning I answered the phone with dread - I knew instantly that it wasn't going to be good news. Four had arrested in development and two were developing slowly but were showing signs of becoming blastocysts, they were at the cavitating morula stage of development. We were advised that we may have to cancel the cycle.

NO NO NO NO NO NO NO NO NO NO NO NO NO NO NO NO NO NO NO NO NO 

HOW CAN THIS BE?

OUR EGGS AND SWIMMERS ARE GOOD? TOP QUALITY YOU SAID.

WHAT WENT WRONG?

The room started spinning and I felt sick. I immediately got on the phone to my Bessie who is travelling in Europe (what would we do without Apple and FaceTime/Viber/WhatsApp? We are in the age of the smart phone and I would be 100% lost without mine).

My Bessie calmed me down, so I could calm my wonderful Hubster down. We were going to go to the clinic, talk to Dr Wren, and I was positive that we were going to transfer. Just because our mini-mes were a bit slow doesn't mean they won't stick. But the journey there was the longest its ever been and it was the most quiet we've ever been. We were supposed to be excited but we were scared.

I was hoping to see my consultant James Nicopoullos but he was on holiday so we saw Dr Wren instead. She was in the main nice but my god she was also VERY blunt. To cut a long story short she said: 'you didn't get pregnant with a 5AA blastocyst so you're not going to get pregnant with these.'

BOOOOOOM - kick me us both in the teeth when we're down why don't you? Up until that morning as far as we were concerned we were on track for a single embryo transfer and hoping to be able to freeze two or three embies for later, but now you tell us four have died and we will need a miracle for the others to progress. A little sensitivity wouldn't go a miss eh? I appreciate that you are a scientist and see everything in black and white but look after your patient's emotions, you work in the field of infertility - by the time ladies have come to you they have been through years of trying for a baby - they're desperate - you're their last hope - your patients have invested EVERYTHING into this process so be mindful of their hearts. You should know better than to say something like that, especially someone in your position. Our mini-mes weren't dead, they were slow, so whilst they are still growing (albeit slowly), there is still hope (even if it is only a glimmer and a miracle is needed).

We took five minutes, we went outside, I called my Bessie on Viber. I didn't know what to do. I felt like I was drowning. On the one hand I have this doctor who I had never met before telling me in no uncertain terms that there is no point in transferring our last two mini-mes (but she'd do it if I wanted her to, the choice was mine), on the other hand I wanted my mini-mes in my womb. I wanted them with me, they'd be better with me than in a petri dish, they belong with me. 

To be told that the only way forward was to abandon your cycle is a million times worse than getting to test day and having a negative. Trust me - I know. I've had a cycle not even let me get to test day and end in a very heavy, painful bleed. I've gotten to test day and got a negative and now I've been told that my cycle is being abandoned and there's not much hope in your remaining embryos progressing - in fact there's no point in transferring. Out of the three scenarios the third is the worst - take my word for it, it sucks.

I felt winded. 
My legs felt weak. 
I was confused. 

I cried and cried and cried. My Bessie cried. My Hubster cried. We all cried.

But you know what? My mini-mes were still going. They might be slow but they are still growing so what did we have to lose? So we transferred them and they are now with me where they belong. Here they are - the one on the left is a bit more developed than the one on the right. They are called cavitating morulas - the stage right before blastocyst.

I've read of day five and day six cavitating morulas resulting in pregnancy. Apparently they usually result in girls? I'm not getting ahead of myself and believing that next week I'll have a positive pregnancy test and I'll be carrying a baby girl - I'm not that silly. I know I need to be positive but not at the expense of dealing with the here and now and the range of emotions that comes with that. I'm being realistic. The opportunity to be cautiously optimistic was taken away from me the moment I was told there's not much point in transferring as I won't get pregnant. They took away my hope. Ladies on the Fertility Friends forum have helped give me a bit of hope, whilst you have an embryo there is always hope (but let's keep that hope in check shall we and not run away with ourselves).

Today my boobs are like rockets, they are swollen and they hurt, so much so I had to wear a sports top to bed with an in-built bra to try and stop them hurting as much. Today I have mild cramping. The hopeful part of my brain tells me that this is a good sign - my embryos would be eight days old (if they are still going), as they were a little slow off the mark the mild cramping could be implantation cramps. But I doubt it. It's the cyclogest pessaries Johanna - YOU KNOW THIS - it's the progesterone, nothing else so stop imagining you're pregnant.

We have a lot of questions.

Why in our cycle at Kings were we able to get five blastocysts but not at The Lister? Why when we were focusing on quality and not quantity were we unable to get the quality we got in our previous cycle? You told us we didn't need IMSI so why did our embryos not develop? What about sperm DNA fragmentation? Did the awful family bust-up a few weeks ago affect the quality of my eggs? Was the stress partly to blame? What went wrong in the lab? How could this happen? 

Questions. Questions. Questions.

We need a miracle. Please let our mini-mes fight and stick and prove everyone wrong.

I started this post with a quote and I'm ending with a different quote. Repressing your emotions is bad for you, and imposing positivity when you are sad is bad. Don't get me wrong - I am a positive kinda girl, but even people who are naturally positive and reject negativity have their sad days. Being sad and being negative are very different things. I'm finding the strength to acknowledge how the past few days have made me feel and I'm dealing with the tough emotions - I'm allowing myself to feel happy believe it or not. In my acknowledgment of my sorrow I can truly be happy as happiness and sorrow are two sides of the same coin. To be truly happy you must be at one with all of your emotions and you must have the strength to live in the here and now. I may be feeling sad, but I'm ok with that - as it's our emotions that makes us human. 

'Joy and sorrow are inseparable…together they come and when one sits alone with you…remember that the other is asleep upon your bed.' 
Khalil Gibran

Laters xx

Bring on the down regulation...

One day till down regulation

Tonight I shall drink a glass of red wine or two or three.
Tonight I shall scoff loads of seriously yummy food and not care if I'm eating more carbs as opposed to protein.
Tonight I'm going to try and remember what the Hubster and I were like before before we embarked on our journey to the land of IF.
Tonight I am going to sleep like a baby in my bed and wrap myself around my duvet in the knowledge that I'm not going to overheat.
Tonight I shall be headache free.
Tonight I'm not going to be anxious.
Tonight I'm not going to flap or fret about the next seven or so weeks.
Tonight I am re-reading my blog entries from earlier this year with a slight sense of trepidation.
Tonight I am relishing an injection free night as tomorrow night marks day one of down regulation - BRING IT ON!!!

The Hubster and I finally had our joint counselling session last week and unlike the ones I have been to by myself this one really choked me up. Going for counselling at the assisted conception unit seems a bit wrong to me - that place is full of baby-related stuff: scans, nurses, hospital gowns, swimmer collection rooms, egg collection theatres, embryo transfers and its where our mini-mes are frozen - it's just so RAW. The counsellor there is lovely, I really clicked with her and so did my Hubster. What caught me off guard and stunted my speech was being asked "when did you lose your baby?" Wow. To finally have someone speak to me so honestly with the acknowledgement that yes - I lost my baby...  and no, I'm not over it which made both the Hubster and I think: WHAT THE HELL ARE WE DOING? 
WHY? 
WHY? 
WHY are we doing this again so bloody quickly when both of us are blatantly not ready for it? I have been warned, if this cycle doesn't work then not only will I be dealing with the three and half years of trying and not conceiving, but also the loss of our baby in February and then the loss of not one but two mini-mes. Seriously, we must be off our rockers? If this doesn't work then I don't know if I'll ever find the old me again, I'm not sure I'll be able to fix us (but I don't have choice really do I?)

BUT I can give you the answer to my questions: we want more than anything to be pregnant, we want to me a Mummy and Daddy and we know we will be bloody brilliant parents. All my fear is quashed under our teeny 20% chance of becoming pregnant. I've decided not to listen to the statistics - I was told I had a 60-70% chance of success on our last cycle and it didn't work so in my head - with two mini-mes being transferred we have just as much chance as anyone. I don't tend to take the easy path with anything so why should this be any different?

So from tomorrow onwards we're back to the injections, I'm off to see Elise (who I am sticking with - it's not practise in the counselling world to have more than one counsellor but I didn't want us to miss our joint appointment at Kings), I'm 100% off the booze, I'm back to listening to my IVF belief CD and I'm waiting for the side affects to kick-in. They took about four days last time round, I have one of my best friend's hen-do this weekend, that is on day five... I'm anxious about being teary, having hot flushes, getting headaches and just not wanting to be there, I'm anxious about watching all my friends get hammered whilst I stay sober - thank goodness for my Bessie being pregnant - both of us are (or were) THE party starters - oh how times have changed! I'm still funny in big groups where you are supposed to be having fun so I'm a bit worried about Saturday - I don't think I'll be my usual up-for-it self but I'll sure as hell give it a go. It'll be my first sober hen-do so we'll see how my stamina goes, it'll be good prep for the wedding as this will be around embryo transfer time - I do pick my moments hey?!

So that's it from me for tonight - I'm going to enjoy my last injection free evening for a good while - let the positive vibes commence, may the chemical menopause symptoms be gentle on me and may all my worry about my heart shattering into a million pieces again be put to rest. From this day onwards for our second cycle - PMA will prevail.

Catch ya later :) x

The final countdown

Embryo Transfer and the dreaded two week wait

Tuesday was ET day, it was a very exciting day and it pretty much marked a conclusion to our IVF treatment; after waiting for so long and then diving headlong into it, and then feeling rubbish (but very upbeat) throughout, would you think it strange if I told you I found this a little sad? Probably!

We got the call from our embryologist around about 9:30am on Tuesday to tell us we had one über top grade blastocyst for transfer and we have a few for freezing, all good quality blastos but the best with the highest possibility of implanting would be meeting me later. Whoop whoop. Despite having quite a few good quality embryos at the three day stage you always worry that they may not live - it has happened but I was ecstatic to hear that ours were still fighting. I gave verbal consent for them to be frozen - we have some babies in the bank so to speak.

Our appointment was at 2:30pm, you need to have a full bladder for ET as it helps the doctor place the embryo in the right section of the womb (the bladder helps flatten out the womb so when it comes to inserting the catheter into your womb - it practically goes in a straight line). Given the sheer amount of liquid I've been drinking to try and beat the OHSS this wasn't a problem, however - we didn't get seen until 3:30pm - I was full to bursting!!! Like egg collection (EC) day, you need to ensure that you're not wearing any makeup (including nail varnish), perfume - anything smelly and the same goes for your significant other - embryos don't like it so you need to make sure when you are going for EC and ET that you are there as God made you. 

ET doesn't hurt and is much like a smear test as it involves a speculum, unlike having a baseline scan you have an ultrasound - it's via the ultrasound the team can see where to transfer the embryo. There were a legion of people in the room with us: the doctor doing the transfer, two other doctors, a trainee doctor and the embryologist. Initially a lovely, petite Indian lady doctor was supposed to do the ET but when I walked into theatre fully gowned up, I was asked if I minded another doctor doing the ET as he wanted try a new softer catheter (a more senior doctor obviously pulled rank)? I didn't really care who did it, as long as they did it properly and got my mini-me in my womb safely - this doctor seemed like he knew how to do the job! You can't be shy if you're having IVF, your foof is on show for everyone to have a look at. As they were trialling a new catheter we had a mock transfer first, this is fine, do as many practice runs as you like as long as when it comes to the real thing - it's done correctly (I didn't doubt the doctor's competence at any time btw). Yes ladies - you can't be shy about this; imagine you are on a dentist like chair with you legs in stirrups, much like a smear there's a speculum and it's clamped in for a good while, your chair is then winched up and there is a bright yellow shining light beaming at your foof where both male and female doctors will be having a look, all to ensure the safe delivery of your mini-me. This is what ET is like! The bonus of all of this is we not only got to see our mini-me hatching out of it's shell in the petri dish on the big plasma screen just before transfer, but we also saw it being inserted into my womb (not very clearly, but you could see it). This was awesome (and it brings a tear to my eye when I think about it - absolutely amazing).

A day five hatching blastocyst - this is what our mini-me looked like before transfer, ripe for attaching and implanting (fingers crossed).

Kings ACU use the Gardener scale for grading Blastocysts, the stage of development of the blastocyst(s) is graded from 1 - 6, and the outer and inner cell masses are graded from A-C. The inner cell mass forms what will become the baby (this is what you can see hatching out of the picture above), the outer cell mass or trophectoderm will become the placenta. The stage of development and quality of the outer and inner cell masses is scored as per the tables below. I've included this technical shizzle as it can be hard to remember everything as and when you're told it due to adrenalin, and given how you are positioned in theatre.

The Gardener blastocyst grading system assigns three seperate quality scores to each blastocyst embryo:

1. Blastocyst development stage - expansion and hatching status
2. Inner cell mass (ICM) score, or quality
3. Trophectoderm (TE) score, or quality

Expansion grade	Blastocyst development and stage status
1	Blastocoel cavity less than half the volume of the embryo
2	Blastocoel cavity more than half the volume of the embryo
3	Full blastocyst, cavity completely filling the embryo
4	Expanded blastocyst, cavity larger than the embryo, with thinning of the shell
5	Hatching out of the shell
6	Hatched out of the shell

ICM grade	Inner cell mass quality
A	Many cells, tightly packed
B	Several cells, loosely grouped
C	Very few cells

TE grade	Trophectoderm quality
A	Many cells, forming a cohesive layer
B	Few cells, forming a loose epithelium
C	Very few large cells

What I am really pleased to say is that our mini-me is a grade 5AA - this is the best type of blastocyst that can be transferred, and from what I understand is a bit like gold dust in the murky world of IVF/ICSI. Grade 6 blastos need to hatch in the womb so I was pleased as punch to see that we now have the best possible chance of success, our mini-me was ripe for implantation, fingers and toes crossed.

Test day is Friday 15 February 2013: gulp. 

This is nine long days away. I am so looking forward to that day but it also scares the be-jesus out of me. It's REALLY hard not to dwell and over analyse every twinge (Google at times can be your own worst enemy). Those cramps I can feel, are they implantation cramps or is it my ovaries groaning with the last bit of OHSS or is it the progesterone pessaries? Questions, questions, questions. And it's because of all these questions, lack of activity and waiting that make the two week wait (or the 11 day wait for a five day transfer as in my case) the hardest part of IVF: am I pregnant or not - please somebody tell me!!! BUT one must wait patiently for the outcome of one's endeavours. There's no point in testing too early as you could get a big fat positive (BFP) due to residual HCG being in your system from the trigger shot done 36 hours prior to egg collection. I know of a friend who tested too early and got a BFP, and then ended up getting a big fat negative (BFN) when it came to test day. I can't put myself through that so I shall have to be patient and wait until the morning of 15 February.

I haven't worked out how I will tell people yet, what I do know, if its a BFN I'm not going to want to talk about it and I won't want to have to repeat the news, and I will crumble but for the minute the Hubster and I remain hopeful. Hopeful that our mini-me is bedding down for some VIP womb action and at the moment it feels like that might be happening but only time will tell, as I said - it could be anything. We have done everything humanly possible to make this work and we have a great chance of success but there are no guarantees.

So I'm signing off for now, the next nine days are going to be long but this is where my IVF Belief CD comes into it's own. The third and final message is about deep relaxation and positive visualisation and it really helps me chill and focus all my positive energy to my womb and our mini-me. I'm going to be listening to it lots. Please sprinkle oodles of baby dust our way and pray we get the result we so want.

Catch ya later :) x

Let's twist again

So I've been in pain, real pain. The type of pain that makes all the colour drain from your face and you need to pant through it. The pain was so bad last night that I actually told the Hubster "I need to go to hospital." Queue blood draining from the Hubster's face, scary times - I don't think I'd realised up until that point how stressful all of this has been on my lovely Hubster. The flat may look like an upside down mess but who am I do have a go at him about that when let's face it - all of his energy has been put into making sure that I'm ok?

The day had started out so well as well, we were up at 8:30am getting ready to go to Kings for embryo transfer (ET). We were told to treat Saturday like ET day and if enough of our little mini-mes had made it to day three and were dividing evenly we could go for a day five (blastocyst) transfer. At 9:15am we got the call from the embryologist to say that 3/4 of our embryos were still going strong and were of a very high quality - we could go for Monday transfer - woo hoo! Absolutely buzzing, this is what I'd been praying for - I knew all my PMA was worth it - go, go, go mini-mes - we're willing you on!

This was the best I'd felt in days, I could actually put my new (stretchy) jeans on as the bloat had decreased and I guess the adrenalin rush had something to do with the feel good factor, so the Hubster and I went out for brunch. Whilst at brunch, my consultant called to check on my symptoms (as it was a Saturday I had the doctor call and not a nurse as usual). I told him I was actually up and out for the first time since Wednesday, the bloat had subsided somewhat but I still was nowhere near 100%. He asked about how much I was peeing and he seemed happy with that, but I'm still under close observation as symptoms of OHSS can fluctuate on an hourly basis. The previous day I had a very bad, sharp stabbing pain in the womb/ovary area, it lasted about 10 minutes then went thankfully. Apparently this is my ovary twisting - WTF?!?! Due to over stimulation my ovaries are very large, they sit independently on both sides of the womb. Sudden movement can make them twist - I had no idea about this. They normally twist back by themselves, if the pain stays, it's what's called an emergency and I'm to call the on-call gyno at Kings ASAP and head to A&E if necessary.

OK!!! I felt reassured to know what that pain was and glad my body had sorted it out by itself. Fast forward 12 hours and I look like a ghost, not communicating with the Hubster other than the odd grunt and pointing at whatever I needed - at that point I was demanding a fresh hot water bottle. It took 30 minutes for the pain to go last night and I was scared, really scared (but I didn't let on to the Hubster how scared I was). Having read the OHSS leaflet again that one of the nurses gave me on Wednesday I've now noticed the section on acute abdominal pain it says to call them immediately if I get it. I never really understood what acute pain was until I got OHSS; I've never felt pain like it - EVER, and I pray I don't feel it again.

After brunch we went to the in-laws, it was there my bloating suddenly came back, I had to undo my jeans and I started waddling again - my pee output had suddenly gone down as well so we rushed home (as much as a person in my condition can rush that is), I got back into bed (boooooo), inhaled some water and then I started peeling again - phew. It's now Sunday morning, the bloat is still there (and as big as ever) but my twisted ovary has twisted itself back - thank f**k for that. I have NEVER felt pain like it.

I've had some well meaning friends try to get me to "think myself better" which normally I am an advocate of but this is something totally different to a bug; do they not think that I have already been willing my body to stop doing what it's doing? My friends should know I'm a glass half full kinda girl so thinking my way out of this horrid condition is already on the agenda. If the power of thought alone was enough to stop my follicles from filling up with protein rich liquid, which then seeps out into my abdomen causing the massive bloat, I really would've kicked this OHSS by now but it ain't as simple as that. Telling me to think myself better is a bit like telling a 15 year old girl who has unwittingly found out she's pregnant (and she doesn't want to be), that she can think herself to not be pregnant! That shizzle doesn't happen! This isn't the lurgy, or a tummy bug or a fit of melodramatic depression, its an overreaction to the Gonal F, it is what it is and it will be gone soon enough; the best thing to do is for me to give-in to what's happening, relax, don't stress about it, drink oodles of liquid and rest, rest, rest. 

I know my friends mean well and if you're reading this and you're one of my well meaning friends who gave me the thinking advice please don't get upset with me, I know none of you want me to go through this and that your heart is in the right place. If you know me at all you'll know that I've read masses on this, I understand the condition and how dangerous it can be and I'm doing what the doctors are telling me to do. All my positivity is being channelled towards our mini-mes, willing them to stay strong and to develop into blastocysts. I finally stumbled across a blog that is as honest as my blog on OHSS - have a read - it really made me feel better and it might give you a better understanding of the excruciating pain that no amount of thought is able to combat; it made me realise that I'm not going mad imagining these symptoms - you just need to look at me to see something isn't right!

Bloated Jojo - not looking too happy about the situation (and most certainly not my most attractive photo but I thought I should share the love). This was taken yesterday (Saturday 2 February 2013) - I'm a bit bigger since then - the irony isn't lost on me that I look rather pregnant!

Despite all of this (and it appears that I have had a rather tough IVF experience so far) I am still in very good spirits. I may have had to jump through hoops with the NHS to get my treatment but you know what? I'm glad I had to jump through hoops as IVF is anything but a quick-fix, it's a long hard slog (physically and emotionally). This is expensive, hardcore, invasive treatment - they need to be certain only the right couples get the treatment.

I'm totally in awe of what the doctors do at Kings and I feel nothing but love for them. The NHS, despite its faults is a wonderful thing and I feel so lucky to be where I am, I am blessed to have my mini-mes dividing away in a petri dish in SE5, I'm a very lucky girl - I just need lady luck to be on my side from this day onwards. I just need one of my mini-mes to take up residence with me and we can get on with getting to know each other. It's gonna happen and I know I'll have some babies left over for another time; I can't possibly have endured all of this for it not to work (and I am banishing those seeds of doubt out of my head this very instant!) Knowing I have mini-mes in a petri dish in SE5 makes me very happy and excited. I know the OHSS is likely to get worse and possibly stay with me for weeks to come if I get pregnant but you know what? I don't care, whatever it takes as two want to become three. Tomorrow is blastocyst transfer day - excited doesn't come close :)

Catch ya later :) x

My own harvest festival

Egg collection and after affects round up

Egg collection was on Wednesday 30 January 2013, its now Friday 1 February and I'm spending another day in bed - oh what I'm going through to get a mini-me - but I'd do it all again - in a heartbeat.

So on EC day I was super calm, chilled and if anything not nervous but EXCITED - really excited. This was the day that the Hubster's DNA and my DNA were going to join to make mini-mes - what's not to be excited about?!

I got told off for admitting to taking a sip of water by the embryologist but we were still allowed to go ahead with the procedure. I won't lie to you - it hurt like a MoFo but I was out of it at the same time so I only remember snippets. The Hubster stayed with me throughout, I have vague recollections of him stroking my hair throughout the whole process. I had a heartbeat monitor and not at any point did it increase, it was a nice constant 70bpm, even when I was told to "take a deep breath in" and then I felt a hot, sharp stabbing pain around my womb / ovaries. The hypnotherapy CDs are obviously working - being relaxed and positive is the name of the game so if you are going through IVF yourself, please chill (and if all else fails, listen to The Orb's little fluffy clouds - works every time - you're allowed to take your iPod in with you if need be, if it helps - do it!!!) I know I bled as I felt them clean me up. I don't recall saying this but every time the embryologist said "deep breath in" I said "no pain, no gain." I winced but I wasn't a pansy and I breathed. This was after all one of the most exciting days of my life. What I'm really chuffed that I remembered was seeing MY EGGS on the big fat plasma screen - I am soooooo glad I was with it for that as it was 100% awesome - there were loads of them! Screw the pain - this is so worth it.

Anyhow, in recovery I zonked out and slept on and off for about an hour. I could hear a lady in the neighbouring cubicle crying her eyes out prior to her EC - if my head wasn't as woozy and my legs worked I would've gone in there, given her a big hug and would've tried to change her fear to excitement. I can't see how getting yourself in such a tizz is going to help matters? Anyhow - I hope the sedative helped her chill - it most certainly did me and I felt the after affects of it for the rest of the day.

The long and short of it is: I had far more than 26 follicles by the time the embryologist started having a rummage (my ovaries obviously went into overdrive last weekend), they got 18, yes 18 eggs (woo hoo) and Hubster's swimmers stood up to the test and did us proud. Another embryologist came to see us once I'd come round from the sedative in recovery and told us that at least 9 of my eggs would be fertilised via ICSI and 6 via conventional IVF. As per the most recent swimmer analysis, the Hubster's swimmers were on the cusp of ICSI/IVF so why not treat them like that and do a combo? Brilliant, the staff at King's really are amazing and I am in awe of them. How cool would it be to tell people that you're an embryologist? Far more exciting than saying you work in Marketing - I really wish science had been made a lot more appealing when I was at school as I now find it all fascinating. I'm going to make it my mission to get my mini-me(s) interested in science and with a bit of luck they'll go one to do something as amazing as this.

Anyhow, I digress, do you want to know what the different is between ICSI and IVF? ICSI stands for: Intra-cytoplasmic sperm injection. This involves injecting a single swimmer directly into the egg to fertilise it - so the swimmer is given a helping hand. Here's a picture to show you the science bit - seriously - these guys are amazing for being able to do this:

Conventional IVF stands for in-vitro fertilisation, this literally means fertilisation in a glass - here's another picture for the science bit:

I am very chuffed that we are having both, the staff at Kings are keen to keep the whole process of baby-making as natural as possible so we have been lucky enough to have the best of both worlds. This however is where my frank honesty of how many eggs and swimmers successfully fertilised ends; I want to keep this private and don't really want the amount of embryos we have currently dividing away out there on the internet (you can understand that hey?) What I can tell you is that we have mini-mes growing in a petri dish and the embryologist called saying "I have amazing news" and it was amazing - lockdown was worth it and I am so excited about everything (despite feeling like a big fat pile of steaming poo). We're booked in for embryo transfer (ET) at 10:30am tomorrow morning (Saturday 2 February 2013). This would be a three day transfer, I'm hoping our little mini-mes stay strong and keep dividing evenly so they can get to blastocyst stage and we can have a five day transfer.

Here's a bit more science: check the image below to see how embryos develop. If you look at the very first embryo picture that has just two small circles in it - these circles represent the DNA from the mother and the father - how cool is that?! I figure that our mini-mes are currently at the eight cell stage, awesome, awesome, awesome. With a bit of luck the progesterone pessaries I'm now on will help one of my mini-mes implant in my nice, think womb - a blastocyst implantation is the aim.

Since my EC I have been feeling rough. The bloating I had with the HCG trigger shot has increased, I look about six months pregnant. It seems I have mild OHSS, it's quite uncomfortable and painful, I've felt queasy and have had some terrible trapped wind! Kings are checking up on me daily, I have a jug I need to pee in and I need to drink at least two litres of water / juice / tea  etc a day, and I need to monitor my pee output. If my output declines rapidly I need to get myself to Kings quick sharp, if I start to feel breathless I need to get to A&E. I feel like crap but I'm still über optimistic - it is what it is and it will go soon enough - its just one of those things. I had yesterday off sick and I'm off sick again today - I was supposed to work form home but sitting up at a laptop for long periods of time is very uncomfortable (this post has been written in segments). Kings are calling me daily and they are concerned and keeping a close eye on me but I figure it'll be gone soon enough and I'll have a mini-me inside me :)

So that's it from me today, despite feeling like poo this is quite possibly the most exciting time of my life.

Catch ya later :) x

It's a little bit funny, this feeling inside...

Day 9 of stims

I have oodles of things that I need to blurt out but I'm feeling a bit confuddled about how I start getting it out - maybe bullet points will help me focus? I'm rapidly approaching the climax of the fertility treatment, when the Hubster has to "do his bit" and I have to get harvested: ARGH!!! Right here goes with the focused bullet points:

• Lady pains...

Ok - so I have had full on pains going on downstairs - I would like to say it felt a bit like ovulation pangs but no, full on lady pains. This is a good thing - it means the Gonal F is doing what it is meant to do and my ovaries are kick-starting back into life. My IVF belief CD bangs on about my womb being a dormant tree bursting into life after winter - well I can tell you that is no longer the case - my follicles are growing like they're going out of fashion and this is the reason for the lady pains.

These pangs tend to make one paranoid about developing Ovary Hyper Stimulation Syndrome (OHSS) - this is one thing I don't want to get. It's when your ovaries go a bit mental and start producing way too many eggs; it can make you very poorly and worst case scenario an ovary can rupture and kill you - yikes. Kings ACU are rather phenomenal and I have been hounding them this week with various questions. The three day headache, the lady pains and a bit of nausea are all signs that you're developing OHSS, but the real sign is water retention and serious bloating along with all of the above - this I don't have - the nurses reassured me that it just means that I'm kicking back into life and womb lining is getting nice and thick: get in!

• Chaps, you may not want to read this section... Lady bodily changes

Right - I haven't mentioned this in my previous entries but one of the things I noticed when I started down regulating, (and I've been debating whether or not I should write about it), was that my boobs seemed to deflate :( They just did not have their joie de vivre anymore. At the time this was the least of my concerns as I just felt so goddam crap - I could've had one massive boob and one teeny-tiny one for all I cared: deflated boobs were the least of my worries! Between hot flushes, tears, headaches, insomnia etc I had enough to try and handle let alone getting myself into a tizz about having to tighten my bra straps!

One of the side affects of injecting buserelin is foof dryness (see The Guide to Assisted Conception Services at King's for the technical list of side affects) - oh yeeeeeaaaaah - just to make you feel that little bit sexier: deflated boobs, mood swings, hot sweaty flushes, headaches, loss of appetite, insomnia, tears, exhaustion - yup - let's just add a dry foof to the mix to make you feel that little bit more feminine hey?! (Chaps I did warn you this bullet point was close to the bone!) Well fast forward to day 9 of stims and a complete 180º has occurred... 

Ladies, if you're trying for a baby and are monitoring when you ovulate you'll all be more than aware that one of the main signs that it's time for some hot lurvin' with the man in your life who you intend on procreating with is: egg white cervical mucus (or as I prefer to refer to it: foo' ju!) This is exactly as it sounds but stretchy - very stretchy. "The Sahara turns to the Nile" as my lovely friend Boki put it just a couple of moments ago! Now, this actually made me panic, I judge such bodily functions as a clear indicator that it's time to get back on the horse so to speak, so when I clocked foo' ju my first thought was "oh shit, what if I'm about to ovulate 20 eggs?" What with the Hubster's newly founded super-swimmers the irony wasn't lost on me that if this was the case there was a strong possibility that I may become pregnant with quads (quasi-naturally)! My rational head kicked in, I called Kings (again), and they told me this is a very, very good thing and its a sign of muchos follicles and no - I won't spontaneously ovulate, my eggs are only going to ripen once I have the HCG jab - phew!

So I've got it out - this shizzle has been on the tip of my tongue since I started this blog, but typical British prudishness took over and I thought there was no way I could put this out into cyberspace. BUT you know what? My opening paragraph of this blog stated I was going to give an open an honest account of what IVF is really like, and for that to happen - this needed to be put out there. I've been unable to find one single article anywhere that actually tells it how it is. You can drive yourself demented trawling through fertility forums trying to find out if egg white cervical mucus is "normal" when on stims, and all you get are thread upon thread of women who are exactly like me trying to find out if this is normal. Naturally, virtual friendships are formed on these forums but I've got enough friends and FB friends that I don't feel the need to forge new relationships online, I just want to know if what I was experiencing was normal.  I feel a need to be open and share my experiences (it's also a great stress reliever and it helps me categorise and file away what is happening to us - it helps me manage our journey and how it makes me feel). When the Hubster and I first started our IVF journey I was obsessed with research and filling my head with as much information as possible, but not once did I read anything about boobs deflating - ladies need to know this stuff so screw you British prudishness! Anyhow, back to my point - I eventually found enough blog entries to kinda put my mind at ease (I still called Kings), but there wasn't anything that cropped up that explained what this is really like. So if I've done one thing (other than make myself feel better through cathartic release), I hope that a woman somewhere on this earth has stumbled across my blog and felt reassured. 

So, it's 12 hours till scan day, getting all of this out has most certainly calmed me; I will be back tomorrow with an update... Do I have oodles of follicles that are at least 18mm in diameter or do I need to continue the daily doo-lally jabs that little bit longer? One thing is for sure, next week is harvest time - we just don't quite know when... Exciting, scary, nerve wracking... EEEEEEK! Think I'll be getting some good value IVF hypnotherapy CD action this evening!

Wish me luck, catch ya later, :) xxx

Stimulation time baby!

Day 17 of down regulation

I started writing this post at 4am mid-insomnia attack two nights back when I wasn't feeling too great. I decided to hold off publishing as I knew my first baseline scan was due and I was keeping my pinkies crossed that I might have good news to report.

Anyhow, the Hubster and I had a good giggle last night - having not eaten that much yesterday and having made several mistakes at work I decided that I needed to snap myself out of my melancholy and cook up a bit fat juicy chicken for dinner: it did the trick it - I inhaled every bit and the Hubster and I were on form.

We were talking about the forthcoming scan and what would happen next in our quest to make a mini-me, I admitted how nervous / scared / excited I am about egg collection day - admitting your fears is quite a hard thing to do - it's taken so long for us to get to this stage I'm not about to start asking any "what ifs?" I'm not even contemplating this not working, tackling that possibility is something I'm not willing or able to do right now and I don't think it's the right attitude to be honest - positivity is the only way for Mr & Mrs C. The Hubster on the other hand  was flapping about doing his forthcoming swimmer sample (not quite sure why - he's well practised in this swimmer sample shizzle) - in all honesty - we were hoping that our three months of lockdown had been worth it and that his swimmers had started swimming in the right direction and there were more of them. Compared to daily jabs that send you doo-lally, getting swimmers into a pot and delivered at Kings' Assisted Conception Unit (ACU) is not only quite an enjoyable experience in comparison to daily doo-lally jabs, but let's face it - it's something that most men should be more than capable of! The Hubster, kindly offered to "wa*k every day" if it meant it would make things better!!! Brilliant! That was nearly the title of this blog but I thought it might not get through the Google listings, but it's nice to know that the Hubster is thinking of me!

Anyhow, today was baseline scan day - OMG - how nervous were we?! We drove to Kings on a very cold morning (even I thought it was a bit chilly), it was so chilly I kept Paul's pot of swimmers under my arm pit to keep them warm! With only an hour allowed from production to delivery, keeping them warm was top priority just in case we got stuck in traffic - if they got too cold they'd start dying and we didn't want that.

We arrived bang on time and got seen at about 11am - a baseline scan - for those of you who don't know is a scan of the womb. Unlike an antenatal scan your bladder must be empty, and the scan is not conducted on your lower belly like when you're pregnant but via your foof! For my first scan this rather alarmed me, but it's nothing really - loads of forums bang on about discomfort and pain but a smear is far, far worse. A baseline scan doesn't hurt at all - you're given a sheet to protect your modesty and the nurse doesn't have a look at your foof, she's more interested in your womb. So if you are reading this and are about to have your first baseline scan please don't flap - it's nothing to worry about and is over really quickly! I don't find the scans that bad as I think its really cool to have a good old look at your womb (as did the Hubster). The scan is to check the lining of your womb and to check that your ovaries are nice and barren; basically it's to check that the daily doo-lally jabs have done what they're supposed to, and you've put yourself through hell and back for a reason - that you've shut down. Your womb lining needs to be no thicker than 5mm thick - even I knew just by looking at the scan that I'd shut down as my womb looked very different when compared to the last time I had a look. I'm very pleased to tell you that and mine is now 4mm thick at best! WOO HOO!!!

So I can move on to the stimulation phase - this is bloody brilliant news. BUT it now means I have to do  two injections a day, I have to stick with 50 units of buserelin a day and start the Gonal F jabs - both jabs at the same time every day, on alternate sides of my belly (apparently I'll start feeling better as my body stocks up on FSH so it's all good). The Gonal F jab is pre-loaded with the follicle stimulation hormone (FSH) so it should be easier to deal with - one injection of each a day for another 10 days and then things will start to moving quickly: VERY EXCITING!

And now for the final bit of good news (drum roll please)... The Hubster's swimmer results are in. There has been a MASSIVE improvement, so much so that we are now on the cusp of having either ICSI (more on that another time) or straight forward IVF, so we are now borderline ICSI/IVF - I can't tell you how impressed I am. So it just goes to show for you chaps out there who are in denial about your manhood and reckon you can drink whatever you want and smoke whatever you want: being well behaved and cutting back on all of those toxins DOES have an impact. If you and your lady are thinking it'd be nice to have a mini-me of your own in a year or two you need to start looking after your health and start tweaking your lifestyle now, and I'm not just talking about cutting back the booze and stopping the fags, I'm talking about vitamins, diet and stress - every aspect of your lifestyle can affect your fertility. Whatever you do don't take your fertility for granted as if you lose it, it can be quite an effort to get it back and before you know it you're off down to your local hospital to have fertility tests. Trust me chaps, ladies are used to getting their foofs checked out but lets face it - you men have issues chatting about your emotions let alone having to get your swimmers analysed by your local NHS trust; if you have the power to do so this should be avoided if at all possible and it's only you chaps who can change that - this is one thing us ladies have no control over. Take it from someone who knows only too well how much anguish this can cause, don't leave baby making to the very last minute thinking you'll get pregnant straight away as that's not always the case (just because so and so did and they were hardcore ravers doesn't mean the same will happen for you), and if you're a lady then I don't even need to mention the dreaded biological clock... I can't tell you what a relief it is to know that three months of exemplary behaviour has actually done something good - that on top of generally winding down over the past 18 months has proven that it can be done, you get what you put in. High-five to the Hubster!

So, I'm signing off for today - next scan is in 10 days time (25 January) and if all is on track, it'll be systems go, go, go! Until then I'm moving on to the 2nd track on my IVF belief CD, I'm keeping positive and taking the side-affects in their stride.

Catch ya later :)